What is Unna thost disease?

What is Unna thost disease?

Unna-Thost palmoplantar keratoderma is a type of diffuse palmoplantar keratoderma that mostly affects the palms of the hands and soles of the feet. It usually begins in early childhood with redness of the palms and soles. The palms and soles gradually become thicker and develop a yellowish, waxy appearance.

How is Palmoplantar Keratoderma treated?

The aim of treatment is to reduce the thickness of the skin and to soften the skin. Treatment options include regular use of emollients, keratolytics such as salicylic acid or urea, antifungal cream or tablets if indicated, topical retinoids/calcipotriol and systemic retinoids.

What causes Keratoderma?

What causes palmoplantar keratoderma? Keratoderma may be inherited (hereditary) or, more commonly, acquired. The hereditary keratodermas are caused by a gene abnormality that results in abnormal skin protein (keratin). They may be inherited either by an autosomal dominant or autosomal recessive pattern.

What is vohwinkel syndrome?

Vohwinkel syndrome is a disorder with classic and variant forms, both of which affect the skin. In the classic form of Vohwinkel syndrome, affected individuals have thick, honeycomb-like calluses on the palms of the hands and soles of the feet (palmoplantar keratoses) beginning in infancy or early childhood.

What is Naxos disease?

Naxos disease is a recessive association of arrhythmogenic right ventricular cardiomyopathy (ARVC) with wooly hair and palmoplantar keratoderma or similar skin disorder.

What is Papillon Lefevre syndrome?

Papillon-Lefèvre syndrome is characterized by the development of dry scaly patches of skin (hyperkeratosis) usually around the age of one to five years. These patches are usually confined to the undersides of the hands and feet, but may spread to the knees and elbows.

Is palmoplantar keratoderma a rare disease?

Diffuse palmoplantar keratoderma with painful fissures is a rare, genetic, isolated palmoplantar keratoderma disorder characterized by non-epidermolytic, diffuse hyperkeratotic lesions affecting both the palms and the soles, associated with a tendency of painful fissuring.

Is palmoplantar keratoderma a disability?

Hypohidrosis-enamel hypoplasia-palmoplantar keratoderma-intellectual disability syndrome is a rare, genetic, syndromic intellectual disability disorder characterized by severe intellectual disability with significant speech and language impairment, hypohydrosis (often resulting in hyperthermia) with normal sweat gland …

How do you treat keratoderma?

Treatment

1. Saltwater soaks.
2. Emollients.
3. Paring (cutting away layers of skin)
4. Topical keratolytics (useful for people with limited keratoderma)
5. Topical retinoids (this is often limited by skin irritation)
6. Systemic retinoids (acitretin)
7. Topical vitamin D ointment (calcipotriol)

Is keratoderma contagious?

An autosomal dominant condition may occur for the first time in an affected individual due to a new mutation, or may be inherited from an affected parent. A person with punctate keratoderma has a 50% chance of passing on the condition to each of his or her children.

What is a syndrome kid?

KID syndrome is a genetic disorder and can be transmitted from a parent to a child in an autosomal dominant fashion. That means that each individual affected with the disease would have one abnormal and one normal copy of the disease gene.

What causes Naxos disease?

Mutations in the genes encoding the desmosomal proteins plakoglobin and desmoplakin have been identified as the cause of Naxos disease.