Who is mostly affected by neurofibromatosis type 2?
Affected Populations NF2 is a rare disorder that affects males and females in equal numbers. All races and ethnic groups are equally affected by this disorder. The estimated incidence of NF2 is 1 in 33,000 people worldwide. The symptoms of this disease typically become apparent during puberty or early adulthood.
What is the life expectancy of someone with neurofibromatosis type 2?
Tumours that develop inside the brain and spinal cord can place a strain on the body and shorten life expectancy. The average life expectancy for someone with NF2 is 65 years of age. Read more about treating neurofibromatosis type 2.
How is neurofibromatosis type 2 caused?
Neurofibromatosis type 2 (NF2) is caused by a faulty gene. If the NF2 gene is faulty, it leads to uncontrolled growths (tumours) developing in the nervous system. In half of all cases of NF2, the faulty gene is passed from a parent to their child.
Which gene is responsible for neurofibromatosis type 2?
Mutations in the NF2 gene cause neurofibromatosis type 2. The NF2 gene provides instructions for making a protein called merlin (also known as schwannomin). This protein is produced in the nervous system, particularly in Schwann cells, which surround and insulate nerve cells (neurons) in the brain and spinal cord.
Does NF2 cause seizures?
Epilepsy Causes for Individuals with Neurofibromatosis Type 2 (NF2) Epilepsy occurs when permanent changes in the brain cause it to be too excitable or irritable. As a result, the brain sends out abnormal signals which might happen once. A single Seizure that does not happen again is not Epilepsy.
Does neurofibromatosis worsen with age?
Neurofibromas may increase in number with age. Bone deformities. Abnormal bone development and a deficiency in bone mineral density can cause bone deformities such as a curved spine (scoliosis) or a bowed lower leg. Tumor on the optic nerve (optic glioma).
Can neurofibromatosis type 2 be cured?
While there is currently no cure for NF2, there are clinical trials available at the Johns Hopkins Comprehensive Neurofibromatosis (NF) Center.
Does NF2 make you tired?
People with NF2 commonly report fatigue or extreme tiredness. This often follows treatment for a brain tumour and can continue even after you have fully recovered from the surgery.
How long can you live with neurofibromatosis?
If there are no complications, the life expectancy of people with NF is almost normal. With the right education, people with NF can live a normal life. Although mental impairment is generally mild, NF1 is a known cause of attention deficit hyperactivity disorder. Learning disabilities are a common problem.