How is Xtandi metabolized?
In vitro, human CYP2C8 and CYP3A4 are responsible for the metabolism of enzalutamide. Based on in vivo and in vitro data, CYP2C8 is primarily responsible for the formation of the active metabolite (N-desmethyl enzalutamide). Enzalutamide is primarily eliminated by hepatic metabolism.
Do Xtandi side effects go away?
Side effects not requiring immediate medical attention Some side effects of enzalutamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.
Can you drink alcohol when taking enzalutamide?
The drinking of alcohol may increase your risk of certain side effects (seizures). Discuss with your doctor before being treated with enzalutamide. Enzalutamide may damage sperm and may harm the baby if used during pregnancy.
What is Xtandi used to treat?
Full Prescribing Information. XTANDI is a prescription medicine used to treat men with prostate cancer that no longer responds to a medical or surgical treatment that lowers testosterone. It is not known if XTANDI is safe and effective in females or children.
How do you take Xtandi for prostate cancer?
Last updated on Dec 1, 2019. • metastatic castration-sensitive prostate cancer (mCSPC). The recommended dose of Xtandi is 160 mg (four 40 mg capsules) administered orally once daily. Xtandi can be taken with or without food [see Clinical Pharmacology ( 12.3 )]. Swallow capsules whole.
How do you take Xtandi 160 mg?
1) DOSAGE AND ADMINISTRATION XTANDI 160 mg (four 40 mg capsules) administered orally once daily. Swallow capsules whole. XTANDI can be taken with or without food. 2.1 Patients receiving XTANDI should also receive a gonadotropin-releasing hormone (GnRH) analog concurrently or should have had bilateral orchiectomy.
What does it mean if my PSA is high while taking Xtandi?
If your PSA (prostate-specific antigen) level rises consistently while on treatment to lower testosterone, it can sometimes mean your prostate cancer is progressing. Talk to your doctor about the types of advanced prostate cancer XTANDI may help treat.