Which of the following drug causes QT prolongation?

Which of the following drug causes QT prolongation?

A long QT interval is most frequently seen with class I and class III antiarrhythmic drugs. Other classes of drugs that cause QTc prolongation include antihistamines, antidepressants, antibiotics, antifungal drugs and antipsychotics (Table 2).

What is the effect of QT prolongation?

QT prolongation increases the risk of developing abnormal heart rhythms, including the life threatening arrhythmia torsades de pointes (TDP). This type of arrhythmia can lead to sudden cardiac death.

Which of the following medications are most likely to cause prolonged QT interval and potentially induced Torsades de Pointes?

(A) Self limiting torsades de pointes (TdP). (B) TdP leading to ventricular fibrillation. Many of the drugs that were initially known to prolong the QT interval were antiarrhythmics, and quinidine was the most commonly implicated agent.

Why hypocalcemia causes QT prolongation?

Hypocalcaemia is a recognised cause of QT prolongation via prolongation of the plateau phase of the cardiac action potential. This causes calcium ion channels to remain open for a longer period, allowing a late calcium inflow and the formation of early after-depolarisations.

Why does prolonged QT cause torsades?

In the long QT syndromes (LQTS), malfunction of ion channels impairs ventricular repolarisation and triggers a characteristic ventricular tachyarrhythmia: torsade de pointes. Symptoms in the LQTS (syncope or cardiac arrest) are caused by this arrhythmia.

Which drugs cause torsades Depointes?

Other drugs that prolong the QT interval and have been implicated in cases of torsade include phenothiazines, tricyclic antidepressants, lithium carbonate, ziprasidone, cisapride, highly active antiretroviral drugs, high-dose methadone, anthracycline chemotherapeutic agents (eg, doxorubicin, daunomycin), some …

Which antibiotics cause prolonged QT interval?

Antimicrobials that are associated with QT prolongation include the macrolides/ketolides, certain fluoroquinolones and antimalarials, pentamidine, and the azole antifungals.

Can hypokalemia cause prolonged QT?

The electrolyte imbalances causing long QT syndrome are hypokalemia, hypocalcemia and hypomagnesemia. Hypokalemia causes inhibition of the rapid delayed rectifier K+ channels, leading to excess sodium influx or a decreased potassium efflux. This excess positive ions causes an extended repolarization resulting in a prolong QTc interval.

Does Phenergan increase QT?

Electrocardiogram qt prolonged is found among people who take Phenergan, especially for people who are female, 60+ old also take medication Ativan, and have Fungal infection. This study is created by eHealthMe based on reports of 19,566 people who have side effects when taking Phenergan from FDA, and is updated regularly.

Does Ativan cause QT prolongation?

Summary. Electrocardiogram qt prolonged is found among people who take Ativan, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Zofran, and have High blood pressure. This study is created by eHealthMe based on reports of 53,004 people who have side effects when taking Ativan from FDA,…

What causes prolonged QT interval?

Electrolyte imbalance, mainly hypokalemia, hypomagnesemia and hypocalcemia, is also a common cause of prolonged QT interval. Finally many metabolic, nutritional, neurological and endocrine pathological conditions have been reported to prolong the QT interval.