What is the work of artesunate?
Artesunate (AS) is a medication used to treat malaria. The intravenous form is preferred to quinine for severe malaria. Often it is used as part of combination therapy, such as artesunate plus mefloquine.
What is the mechanism of action of antimalarial?
Mechanism of Action: In Plasmodium falciparum quinine has been found to inhibit nucleic acid synthesis, protein synthesis, and glycolysis; it also binds with hemazoin in parasitized erythrocytes. Quinine is effective as a malarial suppressant and in control of overt clinical attacks.
Can artesunate cure malaria?
IV artesunate is the first-line drug for treatment of severe malaria in the United States.
Is artesunate the same as artemisinin?
Artesunate is an artemisinin derivative. Artemisinin is extracted from the plant Artemisia annua. Artemisinin and its derivatives have been the most useful drug for malarial treatment in human history. The artesunate has an advantage of a hydrophilic group over other artemisinins which makes it a more potent drug.
What are the indications for artesunate?
Artesunate for Injection is indicated for the initial treatment of severe malaria in adult and pediatric patients. Treatment of severe malaria with Artesunate for Injection should always be followed by a complete treatment course of an appropriate oral antimalarial regimen [see DOSAGE AND ADMINISTRATION].
How is artesunate given?
Artesunate is dispensed as a powder of artesunic acid, which is dissolved in sodium bicarbonate (5%) to form sodium artesunate. The solution is then diluted in approximately 5 mL of 5% dextrose and given by intravenous injection or by intramuscular injection into the anterior thigh.
What is the mode of action of Coartem?
Lumefantrine binds to hemin produced during hemoglobin breakdown, preventing detoxification to crystalline malaria pigment (hemozoin). During the same process, the perOXide group in artemether binds to heme and releases toxic free-radicals.
What are the indications of artesunate?
Why is artesunate diluted with sodium bicarbonate?
Artesunate is poorly soluble in water and has poor stability in aqueous solutions at neutral or acid pH. Artesunic acid is sufficiently soluble in sodium bicarbonate injection (50 mg/ml) to prepare a clear solution [2].