What is Factor V heterozygous?
Heterozygous means that the 2 copies of a gene are different. In your case, one of your Factor V gene codes is for normal clotting Factor V and the other Factor V gene code is for Factor V Leiden. There is more risk of a blood clot if both gene codes are for Factor V Leiden (ie in the homozygous state).
Is Factor V Leiden recessive or dominant?
Genetic counseling: Factor V Leiden thrombophilia (i.e., predisposition to the development of venous thrombosis) is inherited in an autosomal dominant manner. Homozygosity for the Leiden variant (and a much greater risk for venous thrombosis) are inherited in an autosomal recessive manner.
What are the two types of factor V Leiden?
Having 1 Factor V Leiden gene (heterozygous type) slightly increases the chance of developing a blood clot. Having 2 Factor V Leiden genes (homozygous type) makes the risk much greater. Having Factor V Leiden does not appear to increase the chances of developing a heart attack or stroke.
What is factor V Leiden genotype?
Overview. Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. Most people with factor V Leiden never develop abnormal clots.
What is the difference between Factor V and Factor V Leiden?
What is Factor V Leiden Mutation? Factor V Leiden is a common change in a gene that controls a protein called Factor V. Factor V is a protein involved in blood clotting and the Factor V Leiden gene change (also called mutation) is linked to an increase risk of blood clots.
What should you avoid with Factor V Leiden?
If your factor V Leiden requires you to take anticoagulant medication, here are some steps that might help you prevent injury and avoid excessive bleeding:
- Avoid playing contact sports or engaging in other activities that could result in physical injury.
- Use a soft toothbrush and waxed floss.
Should I take aspirin if I have Factor V Leiden?
Though factor V Leiden alone does not seem to raise the risk of arterial clots, something as simple as daily therapy with low-dose aspirin may help prevent a heart attack or stroke in people with factor V Leiden if they have additional risk factors.
Is Factor 5 Leiden bad?
Factor V Leiden is thus a weak risk factor for developing blood clots; in fact, most people who have heterozygous factor V Leiden never develop blood clots. Homozygous factor V Leiden increases the risk of developing clots to a greater degree, about 25- to 50-fold.
How common is homozygous factor V Leiden?
Factor V Leiden is due to an error in the DNA sequence of the Factor V gene. Approximately 1 in 25 people are born with one Factor V Leiden gene, and around 1 in 2,500 are born with two. What problems might I have? You have an increased risk of developing blood clots in the circulation.
What should you avoid with factor V Leiden?
Can you donate blood with Factor V Leiden?
People with factor V Leiden may donate blood, platelets or plasma safely, as long as they are not on an anticoagulant such as warfarin. Only a very few medicines prevent people from donating blood.
Can you donate blood with factor V Leiden?
What is the life expectancy of someone with Factor V Leiden?
Life expectancy is normal as long as you follow doctor’s protocol when it comes to medication, foods, and lifestyles. Most people with Factor V Leiden have no clots in their lifetime the life expectancy can be a normal one.
How to diagnose factor V Leiden?
The gene for Factor V Leiden can be found in a blood sample. A blood clot in the leg or the arm can usually be detected by an ultrasound examination. Clots can also be detected by X-ray after injecting a substance into the blood to make the clot stand out.
What are the chances of getting Leiden factor V?
– Factor V Leiden is a genetic disorder that causes you to have an increased risk of developing abnormal venous blood clots. – It is estimated that between 3% and 8% of the Caucasian (white) U.S. – In the United States, about 5% of Caucasians of European decent and 1% to 2 % of African Americans, Hispanic Americans and Native Americans have the mutation.
What is the treatment for factor V Leiden?
Patients with factor V Leiden who have had deep vein thrombosis or a pulmonary embolism will be treated with anticoagulants (also called blood-thinners), which are medications that prevent blood clots by interrupting the clotting process. Lifelong anticoagulation is not recommended, however, in the absence of additional risk factors.