How does sofosbuvir velpatasvir work?
Velpatasvir is in a class of antiviral medications called HCV NS5A replication complex inhibitors. The combination of sofosbuvir and velpatasvir works by stopping the virus that causes hepatitis C from spreading inside the body.
What disorder does sofosbuvir and velpatasvir Epclusa treat?
Sofosbuvir and velpatasvir is a combination antiviral medicine used to treat chronic hepatitis C in adults and children at least 6 years old or weighing at least 37 pounds (17 kilograms).
What is the drug Epclusa used for?
This medication is a combination of sofosbuvir and velpatasvir and is used to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. It may sometimes be used with another antiviral medication (ribavirin).
How much is a 12 week supply of Epclusa?
How much will Epclusa cost? Gilead has priced a 12-week regimen of Epclusa to cost $74,760. The cost of Epclusa is in-line with, if not a little less than, the other 12-week Hepatitis C medication regimens currently on the market such as Sovaldi and Harvoni which cost $84,000 and $94,500 respectively.
How long after hep C treatment will I feel better?
Most hep C patients report seeing treatment side effects subsiding within a few months or longer. Often it takes six months to a year to regain full energy and feel well. Some patients have reported side effects lingering for longer periods of time.
Can you drink alcohol while taking sofosbuvir velpatasvir?
Avoid alcohol while taking Epclusa (sofosbuvir / velpatasvir). It’s not known if alcohol interacts with the medication, but alcohol and hepatitis C can both damage the liver.
What are the side effects of Sofosbuvir and Velpatasvir?
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- Chest pain or discomfort.
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs.
- lightheadedness, dizziness or fainting.
- skin rash, sometimes with blisters or hive-like swelling.
- slow or irregular heartbeat.
- unconsciousness.
- unusual tiredness.
How do you take Sofosbuvir and Velpatasvir?
For hepatitis C virus infection: Adults—One tablet once a day, taken for 12 weeks. Each tablet contains sofosbuvir 400 milligrams (mg) and velpatasvir 100 mg. Children 3 years of age and older or weighing at least 30 kilograms (kg)—Dose is based on body weight and must be determined by your doctor.
How do you know if Epclusa is working?
After you’ve finished the 12-week Epclusa treatment, you won’t be cured of hepatitis C right away. You’ll be considered “cured” when the hepatitis C virus is no longer detected in your blood. Three months after your treatment is completed, you will have a blood test to see if your treatment was successful.
What is the best time of day to take Epclusa?
Epclusa (velpatasvir / sofosbuvir) can be taken with or without food, but should be taken at the same time every day. Epclusa (velpatasvir / sofosbuvir) is absorbed best in an acidic stomach environment.
Does insurance pay for Epclusa?
The cost for Epclusa oral pellet (150 mg-37.5 mg) is around $26,026 for a supply of 28 pellet, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
What is velpatasvir used to treat?
Velpatasvir is a small molecule direct-acting antiviral used in the treatment of hepatitis C in combination with sofosbuvir. Velpatasvir prevents viral replication by inhibiting non-structural protein 5A (NS5A). At a dose 5 times the recommended dose, velpatasvir does not prolong QTc interval to any clinically relevant extent.
What is sofosbuvir-velpatasvir (Epclusa)?
Sofosbuvir-Velpatasvir (Epclusa) Bottle Epclusa (ep-KLOO-suh) is a fixed dose combination of sofosbuvir and velpatasvir ( Figure 1 ). It is manufactured by Gilead Sciences.
Is sofosbuvir-velpatasvir safe for patients with renal impairment?
Accordingly, no dosage recommendation has been given for patients with severe renal impairment or end-stage renal disease requiring dialysis. Hepatic Impairment: For patients with mild, moderate, or severe hepatic impairment (Child-Pugh Class A, B, or C), no dosage adjustment for sofosbuvir-velpatasvir is recommended.
How do you take sofosbuvir and velpatasvir together?
Sofosbuvir-Velpatasvir (Epclusa) Tablets Sofosbuvir-velpatasvir is available as a coformulated, once-daily single-pill combination (Figure 2) of sofosbuvir 400 mg and velpatasvir 100 mg. The recommended dose is one tablet once daily, taken with or without food.