What is mip1a?
Macrophage inflammatory protein-1 alpha (MIP-1α/CCL3) is a chemotactic chemokine secreted by macrophages. It performs various biological functions, such as recruiting inflammatory cells, wound healing, inhibition of stem cells, and maintaining effector immune response.
What is the function of CCL3?
Function. CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes through binding to the receptors CCR1, CCR4 and CCR5.
What is mip1b?
Function. CCL4, also known as Macrophage inflammatory protein-1β (MIP-1β) is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is a major HIV-suppressive factor produced by CD8+ T cells.
What is rantes in immunology?
RANTES (CCL5) is a chemokine expressed by many hematopoietic and non-hematopoietic cell types that plays an important role in homing and migration of effector and memory T cells during acute infections. The RANTES receptor, CCR5, is a major target of anti-HIV drugs based on blocking viral entry.
Is IL 6 a proinflammatory?
IL-6 exhibits two contrasting features. In models of chronic inflammatory diseases, such as collagen-induced arthritis, murine colitis, or experimental autoimmune encephalomyelitis, IL-6 is proinflammatory [28,29], whereas in models of acute inflammation IL-6 exhibits an anti-inflammatory profile [10].
What is CCl3 chemistry?
Trichloromethyl radical | CCl3 – PubChem.
What is the structure of CCl3?
Trichloromethanide
| PubChem CID | 119237 |
|---|---|
| Structure | Find Similar Structures |
| Molecular Formula | CCl3- |
| Synonyms | Methane, trichloro-, ion(1-) trichloromethanide 14478-07-0 Trichloromethane ion(1-) DTXSID70162801 |
| Molecular Weight | 118.37 |
What does a high CCL4 mean?
High chemokine CCL4 expression is associated with colorectal cancer. Given that IL-8, MIP-1beta, and MCP-1 are chemokines that play important roles in recruitment of immunocompetent cells for immune defense and tumor cell clearance, the observed lower levels of these markers with increasing PM2.
What is rantes cytokine?
RANTES (Regulated upon Activation, Normal T Cell Expressed and Presumably Secreted) is a chemokine secreted by platelets that have been activated predominantly during flow conditions. 118–121. This chemokine interacts with P-selectin in mediating monocyte/macrophage infiltration into atherosclerotic lesions.
What is the difference between chemokines and cytokines?
Cytokines are the general category of messenger molecules, while chemokines are a special type of cytokine that direct the migration of white blood cells to infected or damaged tissues. Both use chemical signals to induce changes in other cells, but the latter are specialized to cause cell movement.
What is the difference between G-CSF and GM-CSF?
The G-CSF receptor (G-CSFR; CD114) is a homo-oligo-dimer, whereas the GM-CSF receptor (GM-CSFR; CD116) is a hetero-oligo-dimer sharing a β-chain with the IL-3 and IL-5 receptors. The G-CSFR is expressed primarily on neutrophils and bone marrow precursor cells.
How is MIP-1α expressed in human cells?
Human and mouse MIP-1α are active on human and murine haematopoietic cells 8. MIP-1α is not expressed constitutively in most cells (with some exceptions), but rather expression occurs as a result of celluolar activation either by cytokine stimulation or intracellular infection.
Is MIP-1α a chemokine?
MIP-1α is a chemokine produced by MM cells in 70% of patients that is a potent inducer of human OCL formation. MIP-1α acts as a chemotactic factor for OCL precursors and can induce differentiation of OCL progenitors, contributing to OCL formation [41–43] independent of RANKL.
What is the role of MIP-1α in bone marrow transplantation?
MIP-1α also plays an important role in homing of MM cells to the bone marrow, and increases adhesive interactions between MM cells and marrow stromal cells by increasing expression of β 1 integrins on MM cells.
What are Macrophage Inflammatory Proteins (MIP)?
Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1α and MIP-1β that are now officially named CCL3 and CCL4, respectively. Both are major factors produced by macrophages after they are stimulated with bacterial endotoxin.