What is factor 2 prothrombin mutation?

What is factor 2 prothrombin mutation?

Prothrombin gene mutation (or Factor II mutation or Prothrombin G20210A) is an inherited condition that increases your predisposition to develop abnormal blood clots in the veins (deep vein thrombosis or DVT) and lungs (pulmonary embolism or PE).

What do you do if you have a prothrombin mutation?

Is there any treatment for Prothrombin Gene Mutation? No treatment to change genes is currently available. Most people who have the Prothrombin Gene Mutation do not require any treatment but need to be careful at times when the risk of getting a blood clot may be increased (e.g. after surgery, during long flights etc).

How many people have Factor 2 mutations?

The mutation is uncommon in African Americans (approximately 0.5%) and is rare in Asians, Africans, and Native Americans. The homozygous form is considered uncommon, with an expected occurrence of approximately 1 in 10 000 individuals. The prothrombin 20210 mutation is equally as common in men and in women.

What is factor 2 blood disorder?

Factor II deficiency is a very rare blood clotting disorder. It results in excessive or prolonged bleeding after an injury or surgery. Factor II, also known as prothrombin, is a protein made in your liver. It plays an essential role in blood clot formation.

How common is factor 2?

Factor II (Prothrombin) Deficiency The incidence is estimated at 1 in 2 million in the general population. Factor II deficiency is inherited in an autosomal recessive fashion, meaning that both parents must carry the gene to pass it on to their children; it affects men and women equally.

Is prothrombin gene mutation curable?

No treatment can prevent the prothrombin gene mutation or make it go away. The goal of treatment is to prevent blood clots (see next question and page 7). If you have had a blood clot, you may be treated with medications called anticoagulants.

Can I donate blood with prothrombin gene mutation?

People with factor V Leiden may donate blood, platelets or plasma safely, as long as they are not on an anticoagulant such as warfarin. Only a very few medicines prevent people from donating blood.

Is Factor 2 mutation rare?

A change in the prothrombin gene is present in 2-4% (or 1 in 50 to 1 in 25) of Caucasians, and is more common in individuals of European ancestry. In the United States, approximately 0.4% (about 1 in 250) of African Americans also have the mutation. Prothrombin G20210A mutation is rare in other groups.

How is factor 2 diagnosed?

Testing. Diagnosis is made with a prothrombin time (PT) test and an activated partial thromboplastin time (aPTT) test. Levels of prothrombin deficiency can range from 2% to 50% of normal. Patients with levels near or at 50% of normal have little to no bleeding problems.

Can you have a baby with prothrombin gene mutation?

The second most common genetic type is prothrombin thrombophilia, which mainly affects people of European ancestry. It involves a mutation in the F2 gene. Genetic types of thrombophilia may raise the risk of multiple miscarriages, but most women with these genetic mutations have normal pregnancies.

What is the difference between factor 2 and Factor 5?

Variants to Factor V and Factor II may affect a patient’s risk of blood clotting problems. The Factor V variant known as Factor V Leiden (or rs6025) is associated with an approximately 300% increased risk in heterozygotes and an up to 8000% increased risk in homozygotes.

How does factor 2 affect pregnancy?

People with this genetic condition have a prothrombin mutation, also called a prothrombin G20210A or a factor II mutation. Most people with prothrombin mutations will never develop an abnormal blood clot. But women who are pregnant already have a higher risk of getting a clot during and right after pregnancy.

What happens if you have a mutation in prothrombin?

People who have a mutation in the prothrombin gene produce more prothrombin protein than is normal. Since there is more of the prothrombin protein in the blood, this increases the tendency to form clots. Prothrombin testing is done by taking a blood sample, and using a genetic test to look at the prothrombin gene.

What is prothrombin 20210 mutation (Factor II mutation)?

Prothrombin 20210 Mutation, also called Factor II Mutation is a genetic condition that causes an increase in the likelihood of your blood forming dangerous blood clots. All individuals make the prothrombin (also called factor two) protein that helps blood clot.

What is prothrombin deficiency (type 1)?

One step of the process involves prothrombin binding to platelets, which helps the body form clots. When there are disease causing changes to the F2 gene, not enough working prothrombin protein is made, so the body cannot form clots properly. [1] [3] There are two types of inherited prothrombin deficiency, type I and type II.

What is prothrombin thrombophilia?

Prothrombin thrombophilia is an inherited disorder of blood clotting. Thrombophilia is an increased tendency to form abnormal blood clots in blood vessels. People who have prothrombin thrombophilia are at somewhat higher than average risk for a type of clot called a deep venous thrombosis, which typically occurs in the deep veins of the legs.