What type of gene is BARD1?

What type of gene is BARD1?

BARD1 (BRCA1 Associated RING Domain 1) is a Protein Coding gene. Diseases associated with BARD1 include Breast Cancer and Hereditary Breast Ovarian Cancer Syndrome. Among its related pathways are Regulation of TP53 Activity and Cell Cycle Checkpoints.

Is BARD1 a tumor suppressor gene?

BARD1 protein is encoded by sequences on chromosome 2q35 and forms a functional heterodimer with BRCA1 through the binding of their RING-finger domains which functions as tumor-suppressor in breast and ovarian cancer [1,2,3,4].

What is BARD1 breast cancer?

BARD1 is a Low/Moderate Breast Cancer Risk Gene: Evidence Based on an Association Study of the Central European p.

Is BARD1 and BRCA1 the same?

BRCA1-associated ring domain 1 (BARD1) is the main binding partner of BRCA1 and is essential for the tumour-suppressor functions of BRCA1. The BARD1–BRCA1 heterodimer has ubiquitin ligase activity that targets proteins involved in cell-cycle regulation and DNA repair for degradation.

What does the BARD1 gene do?

BARD1 is a gene that works with the BRCA1 gene to repair damaged DNA in your body.

What does BARD1 stand for?

The name BARD1 stands for ” BRCA1 Associated Ring Domain 1.” BARD1 is located on chromosome 2. The BARD1 gene works with BRCA1 to repair damaged DNA .

What does BARD1 gene do?

What is BRCA1 and BRCA2?

What are BRCA1 and BRCA2? BRCA1 (BReast CAncer gene 1) and BRCA2 (BReast CAncer gene 2) are genes that produce proteins that help repair damaged DNA. Everyone has two copies of each of these genes—one copy inherited from each parent.

What is the length of BARD1 protein?

The human BARD1 protein is 777 amino acids long and contains a RING finger domain (residues 46-90), four ankyrin repeats (residues 420-555), and two tandem BRCT domains (residues 568-777).

BRCA1-associated RING domain protein 1 is a protein that in humans is encoded by the BARD1 gene. The human BARD1 protein is 777 amino acids long and contains a RING finger domain (residues 46-90), four ankyrin repeats (residues 420-555), and two tandem BRCT domains (residues 568-777).

Is BARD1 a heterodimer of BRCA1?

BARD1 and BRCA1 form a heterodimer via their N-terminal RING finger domains. The BARD1-BRCA1 interaction is observed in vivo and in vitro and is essential for BRCA1 stability. BARD1 shares homology with the two most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain.

Can we predict the Cancer Association of BARD1 variants by DNA repair?

These findings improve the understanding of BARD1 functional domains in DNA repair and support that this functional assay is useful for predicting the cancer association of BARD1 variants. RACK1 regulates centriole duplication by controlling localization of BRCA1 to the centrosome in mammary tissue-derived cells.