What is Basaloid pattern?
The basaloid pattern was characterised according to the 1999 and 2004 WHO classifications by a proliferation of relatively small cells presenting a typical high mitotic rate, forming a lobular pattern with peripheral palisading and comedo-type necrosis 10, 11.
Which molecular test are done in lung cancer?
Table 2.
| Category | Mutation | Amplification |
|---|---|---|
| PCR-based methods | qPCR | |
| NGS | NGS | |
| RNA | Real-time PCR (mRNA overexpression) | |
| Protein | IHC (mutation-specific antibody) | IHC (protein overexpression) |
What is squamous cell carcinoma with Basaloid features?
Basaloid squamous cell carcinoma (BSCC) is a rare and aggressive variant of oral squamous cell carcinoma with a predilection for the tongue and in other locations, such as floor of the mouth, palate, retromolar trigone, and gingival mucosa.
Is Basaloid squamous cell carcinoma treatable?
BSCC has a propensity for nodal spread and systemic metastases. Various treatment modalities have been reported, including surgical excision supplemented with radiotherapy/adjuvant chemotherapy[2–7]. There is no established consensus on treatment because of the limited number of cases of BSCC.
What is a Basaloid neoplasm?
Basaloid tumors of the salivary glands are a heterogeneous group of benign and malignant lesions characterized by small tumor cells with round or ovoid nuclei surrounded by a thin rim of cytoplasm.
What is first line treatment for NSCLC?
In advanced NSCLC, chemotherapy is recommended as first-line treatment in patients with good performance status. Treatment objectives are survival, quality of life and symptom control improvement. Cisplatin-based chemotherapy with one of the effective regimens should be used.
What is considered advanced NSCLC?
When NSCLC is diagnosed as stage 3 or stage 4, it is considered advanced.
What causes Basaloid squamous cell carcinoma?
In basaloid squamous cell carcinoma, the DNA that controls these cells is damaged, leading to an overgrowth of cells that forms a tumor. The exact cause of why this happens in some people and not others is unknown, but factors like smoking and drinking alcohol may be related to the cause of this cancer.
Is Basaloid neoplasm malignant?
What is Basaloid cell?
Basal cells are found at the bottom of the epidermis — the outermost layer of skin. Basal cells produce new skin cells. As new skin cells are produced, they push older cells toward the skin’s surface, where the old cells die and are sloughed off.
Is NSCLC curable?
Treating stage 0 NSCLC Because stage 0 NSCLC is limited to the lining layer of the airways and has not invaded deeper into the lung tissue or other areas, it is usually curable by surgery alone. No chemotherapy or radiation therapy is needed.