What drugs are glycoprotein IIb IIIa inhibitors?

What drugs are glycoprotein IIb IIIa inhibitors?

Glycoprotein IIb/IIIa Inhibitors

• abciximab.
• Aggrastat.
• eptifibatide.
• Integrilin.
• ReoPro.
• tirofiban.

How do GP IIb IIIa inhibitors work?

Glycoprotein IIb/IIIa inhibitors are frequently used during percutaneous coronary intervention (angioplasty with or without intracoronary stent placement). They work by preventing platelet aggregation and thrombus formation. They do so by inhibition of the GpIIb/IIIa receptor on the surface of the platelets.

What class of drug is abciximab?

Abciximab is a monoclonal anti-glycoprotein IIb/IIIa receptor antibody used to prevent thrombosis during percutaneous coronary intervention. Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3.

What is a glycoprotein and what does it do?

Glycoproteins are molecules that comprise protein and carbohydrate chains that are involved in many physiological functions including immunity. Many viruses have glycoproteins that help them enter bodily cells, but can also serve to be important therapeutic or preventative targets.

What is glycoprotein IIb?

In medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is a receptor for fibrinogen and von Willebrand factor and aids platelet activation.

Is aspirin an ADP inhibitor?

Several antiplatelet drugs are often given together while weighing the risk of bleeding against benefit of preventing thrombosis. The classes of antiplatelet drugs are: Cyclooxygenase inhibitors (aspirin) Adenosine diphosphate (ADP) receptor inhibitors (clopidogrel [Plavix], prasugrel [Effient], ticlopidine [Ticlid])

Can abciximab cause thrombocytopenia?

Profound abciximab induced thrombocytopenia has an incidence of 8.5%. It occurs rapidly after drug infusion (within 2–4 h); upon discontinuation of abciximab, platelet values return to normal in 2–5 days, but may be prolonged past 10 days.

Why is abciximab no longer available?

Supplies of abciximab (ReoPro; Janssen Pharmaceuticals) are running low or have dried up altogether, following a manufacturing snafu affecting stocks of the glycoprotein IIb/IIIa Inhibitor around the globe.

What do glycoproteins do for viruses?

What is difference between protein and glycoprotein?

is that protein is (biochemistry) any of numerous large, complex naturally-produced molecules composed of one or more long chains of amino acids, in which the amino acid groups are held together by peptide bonds while glycoprotein is (protein) a protein with covalently bonded carbohydrates.