How do you interpret HLA-B27 results?
Ask your healthcare provider what your test results mean for you. A negative result means you don’t have HLA-B27 in your blood. A positive result means HLA-B27 was found in your blood. You may have a higher-than-average risk of certain autoimmune diseases, such as ankylosing spondylitis and reactive arthritis.
What does it mean if you are HLA-B27 positive?
A positive test means HLA-B27 is present. It suggests a greater-than-average risk for developing or having certain autoimmune disorders. An autoimmune disorder is a condition that occurs when the immune system mistakenly attacks and destroys healthy body tissue.
How common is HLA-B27 positive?
It is present in only 1.4-8% of the general population (higher in certain Native American groups and Scandinavians). Of patients with acute anterior uveitis, 50-60% may be HLA-B27 positive. Both racial background and national origin affect this rate of incidence.
How is HLA-B27 positive treated?
Conclusions: Infliximab, adalimumab, and etanercept were effective for treating and reducing the number of uveitis relapses in HLA-B27-positive AS.
Is HLA-B27 life threatening?
The presence of HLA-B27 on your white blood cells can cause your immune system to attack those otherwise healthy cells. When this occurs, it can result in an autoimmune disease or immune-mediated disease, such as juvenile rheumatoid arthritis or ankylosing spondylitis.
Does HLA-B27 cause rheumatoid arthritis?
HLA-B27 is not associated with RA. The genetic predisposition and environmental factors will start an autoimmune reaction and antibodies will attack the synovium, soft tissue, causing inflammation and gradual destruction in the organs.
Is HLA-B27 positive curable?
There’s no cure for ankylosing spondylitis (AS), but treatment is available to help relieve the symptoms. Treatment can also help delay or prevent the process of the spine joining up (fusing) and stiffening.
What diseases are associated with HLA?
Molecular interaction: MHC-peptides and autoimmune diseases
- Rheumatoid arthritis (RA)
- Multiple sclerosis (MS)
- Systemic lupus erythematosus (SLE)
- Type 1 diabetes mellitus (T1D)
- Sjögren’s syndrome (SS)
- Celiac disease (CD)
- Ankylosing spondylitis (AS)
What is HLA-B27 blood test?
What is HLA-B27 Blood Test? HLA-B27 stands for human leukocyte antigen B27. This HLA-B27 is a blood test to check for a specific protein on your white blood cell that could trigger an auto-immune disease such as Ankylosing Spondylitis (AS). Most of the HLA (antigen) protects the body from harm but HLA-B27 is just the opposite.
What is the human leukocyte antigen B27?
The protein is called human leukocyte antigen B27 (HLA-B27). Human leukocyte antigens (HLAs) are proteins that help the body’s immune system tell the difference between its own cells and foreign, harmful substances. They are made from instructions by inherited genes.
What is the relationship between HLA-B27 and uveitis?
These people tend to have more severe symptoms, non-joint symptoms (e.g., uveitis), and it tends to last longer. In the West, 50% of cases of anterior uveitis is associated with a positive HLA-B27 and about half of these people will develop spondyloarthritis.
Does HLA-B27 cause spondyloarthritis?
In some cases, the HLA-B27 protein can cause the immune system to attack the otherwise healthy cells of the body resulting in auto-immune diseases. In terms of statistics, only 10 to 15% of the individuals carrying this protein will end up getting affected by some form of spondyloarthritis.