How to prepare nanoemulsion?
Nanoemulsions are prepared by the spontaneous emulsification method (titration method). They can be prepared simply by blending oil, water, surfactant, and cosurfactant, in the right proportion, with mild agitation.
Why nanoemulsions are thermodynamically unstable?
Nanoemulsions are thermodynamically unstable systems, in contrast to microemulsions, because some nanoemulsions need significant energy to be formed. Hydrophobic and hydrophilic drugs can be formulated in nanoemulsions.
What is nanoemulsion technology?
Nanoemulsions are nano-sized emulsions, which are manufactured for improving the delivery of active pharmaceutical ingredients. These are the thermodynamically stable isotropic system in which two immiscible liquids are mixed to form a single phase by means of an emulsifying agent, i.e., surfactant and co-surfactant.
How do you stabilize a nanoemulsion?
The stabilization of nanoemulsions, nanosized oil droplets dispersed in water, is commonly achieved through the addition of surfactants and polymers.
What is the particle size for microemulsion?
about 10 to 300 nm
A microemulsion is a thermodynamically stable fluid. It is different from kinetically stable emulsions which will be break into oil and water over time. The particle size of microemulsions ranges from about 10 to 300 nm. Because of the small particle sizes, microemulsions appear as clear or translucent solutions.
How do you make a microemulsion?
Microemulsion systems were prepared by mixing oil with the mixture of surfactant and cosurfactant, and water was added precisely into oily phases with magnetic stirring (300 r/min) at 37°C.
Is nanoemulsion thermodynamically stable?
Nanoemulsions are isotropic and thermodynamically stable dispersions consisting of oil, surfactants, co-surfactants and aqueous phase, usually with a droplet diameter within the range of 10-100 nm.
What is surfactant in nanoemulsion?
Abstract: Surfactants are used to stabilize nanoemulsions by protecting their physical stability and preventing deterioration of the entrapped bioactive during processing and storage.
What is microemulsion method?
The microemulsion technique promises to be one of the versatile preparation method which enables to control the particle properties such as mechanisms of particle size control, geometry, morphology, homogeneity and surface area.
What are the methods of preparing nanoemulsions?
High and low energy methods are used to prepare nanoemulsions, including high pressure homogenization, ultrasonication, phase inversion temperature and emulsion inversion point, as well as recently developed approaches such as bubble bursting method.
What are the ingredients of nanoemulsion?
Preparation of Nanoemulsion Drug poorly water soluble drug eg: CBZ, Diclofenac, Ramipril Oil phase eg: dimethicone oil , castor oil , Soyabean oil Aqueous phase Surfactant Cremphore, lecithin Cosurfactant : Propylene glycol, polysorbate 80, cetylphosphate, hydrogenated caster oil 20.
How do you make nanonanoemulsions?
Nanoemulsion preparation The nanoemulsions were prepared from a mixture of Mint essential oil and Parsley aqueous extract by homogenizing at 18000 rpm for 30 min with different percentages in presence of Tween 80 and Span 80 surfactants (Table 1).
What are the advantages of nanoemulsions?
Their small size leads to useful properties such as high surface area per unit volume, robust stability, optically transparent appearance, and tunable rheology. Nanoemulsions are finding application in diverse areas such as drug delivery, food, cosmetics, pharmaceuticals, and material synthesis.