What is indocyanine green dye?
Indocyanine green injection is a medical dye used in tests to help determine the cardiac (heart) output, liver function, and blood flow in the liver. It is also used to help certain parts of the eye to become more visible during medical procedures such as angiography.
What is indocyanine green made of?
Indocyanine Green for injection USP is a sterile, lyophilized green powder containing 25 mg of Indocyanine Green with no more than 5% sodium iodide. It is packaged with Sterile Water for injection, USP used to dissolve the Indocyanine Green. Indocyanine Green for injection USP is to be administered intravenously.
Is indocyanine green nephrotoxic?
The most widely adopted reagent for NIRF in urologic surgery is the fluorescent dye, indocyanine green (ICG). ICG is non-nephrotoxic, excreted exclusively by the liver, with inci- dences of minor and major complications being exceedingly rare [1].
Does indocyanine green contain iodine?
Indocyanine green may cause laboratory test interference with radioactive iodine uptake studies. Because indocyanine green contains iodine, the iodine-binding capacity of thyroid tissue may be reduced for at least 1 week after indocyanine green administration.
How does indocyanine green work?
ICG is a tricarbocyanine dye which fluoresces, i.e. emits light, after excitation under near-infrared light at 806 nm light. ICG is highly soluble in water and binds to β-lipoproteins, particularly to albumin. Because of the high protein content of lymph, ICG accumulates in the lymphatic pathways and lymph nodes.
When do you give indocyanine green?
Conclusions. In the present study, the optimal timing of indocyanine green administration for fluorescent cholangiography during laparoscopic cholecystectomy using the PINPOINT Endoscopic Fluorescence Imaging System was 15 h before surgery.
Is IC Green radioactive?
Indocyanine green (ICG) is a cyanine dye used in medical diagnostics. It is used for determining cardiac output, hepatic function, liver and gastric blood flow, and for ophthalmic angiography. It has a peak spectral absorption at about 800 nm….Indocyanine green.
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| Hazard statements | H315 , H319 , H335 |
Is indocyanine green a contrast?
Nanoparticles 100 nm in diameter containing indocyanine green (ICG) have been developed as a contrast agent for photoacoustic (PA) imaging based on (photonic explorers for biomedical use by biologically localized embedding PEBBLE) technology using organically modified silicate (ormosil) as a matrix.
What does indocyanine green bind to?
Indocyanine Green Clearance ICG is a water-soluble tricarbocyanine dye that binds to albumin and distributes rapidly and uniformly in the blood after intravenous injection. ICG is exclusively cleared from the bloodstream by the liver in a similar manner to bilirubin and toxins, and then excreted unchanged into bile.
Can you mix ICG with saline?
ICG administration is to be performed via a central or peripheral venous line. Inject the prepared weight-scaled dose of ICG solution into the central or peripheral line as a tight bolus and immediately followed by a bolus of 10-12 mL of normal saline for injection.
What is fluorescence imaging spectroscopy?
Fluorescence spectroscopy studies fluorescent components directly in a food matrix. Hyperspectral fluorescence imaging additionally reveals spatial distribution of fluorescent components in a sample. Fluorescence spectra and images may both be considered as unique sample fingerprints.
What is indocyanine green used for in medical terms?
Indocyanine green. Indocyanine green (ICG) is a cyanine dye used in medical diagnostics. It is used for determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography. It has a peak spectral absorption at about 800 nm.
What is indindocyanine green (ICG clearance)?
Indocyanine green (ICG) clearance is the quantitative measure of hepatic function most used worldwide. ICG is a water-soluble tricarbocyanine dye that binds to albumin and distributes rapidly and uniformly in the blood after intravenous injection.
Is indocyanine green safe for intraocular staining?
Indocyanine green is a dye that has been used to measure cardiac output, liver function, and in ophthalmic angiography. Indocyanine green is used to staining the anterior capsule and internal limiting membrane of the eye to facilitate their removal. The safety of intraocular indocyanine is still of concern.
How do you dissolve indocyanine green for injection USP?
Under sterile conditions, the Indocyanine Green for Injection USP powder should be dissolved with the Sterile Water for Injection, USP provided for this product, and the solution used within 6 hours after it is prepared. If a precipitate is present, discard the solution.