What is the mechanism of action of daptomycin?
Daptomycin has a distinct mechanism of action, disrupting multiple aspects of bacterial cell membrane function. It inserts into the cell membrane in a phosphatidylglycerol-dependent fashion, where it then aggregates. The aggregation of daptomycin alters the curvature of the membrane, which creates holes that leak ions.
What type of drug is daptomycin?
Daptomycin is an antibiotic that is used to treat bacterial infections of the skin and underlying tissues, and infections that have entered the bloodstream. Daptomycin is used for complicated infections, including MRSA or “super bug” infections.
What does daptomycin treat?
Daptomycin injection is used to treat complicated skin and skin structure infections (cSSSI). It is also used to treat infections in the bloodstream, including right-sided infective endocarditis. Daptomycin belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth.
What organisms does daptomycin cover?
Daptomycin is a cyclic lipopeptide antibiotic derived from the organism Streptomyces roseosporus. Daptomycin is used to treat various bacterial infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).
How is daptomycin administered?
In adults, Daptomycin is given by intravenous infusion (see section 6.6) and administered over a 30-minute period or by intravenous injection (see section 6.6) and administered over a 2-minute period.
Does daptomycin penetrate CSF?
After correcting for daptomycin protein binding, the penetration of daptomycin into the CSF was determined to be 11.5% (21).
Is daptomycin used for sepsis?
April 11, 2012 (London, United Kingdom) — Daptomycin (Cubicin, Novartis) achieves clinical cure rates of 72% in sepsis caused by Staphylococcus aureus and of 85% in sepsis caused by Staphylococcus epidermidis.
Is daptomycin used for MRSA?
Daptomycin is an important drug used in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infection. A high dose of daptomycin is indicated for an MRSA infection with a minimum inhibitory concentration (MIC) of 1 mg/L for daptomycin.
Is daptomycin oral or IV?
Daptomycin is administered intravenously in 0.9% sodium chloride (see section 6.6). Daptomycin should not be used more frequently than once a day. Creatine phosphokinase (CPK) levels must be measured at baseline and at regular intervals (at least weekly) during treatment (see section 4.4).
Does daptomycin cross the blood brain barrier?
Daptomycin does not cross the blood–brain barrier and does not penetrate the cerebrospinal fluid of normal individuals.
Does linezolid cross blood brain barrier?
The presence of the blood-brain barrier restricts the entry of drugs into cerebrospinal fluid (CSF) (17). However, linezolid has shown good penetration into CNS, achieving levels in CSF 30 to 70% of those present in serum (13), and thus, it seems to be a promising tool for the treatment of CNS infections (26).
What is daptomycin used to treat?
Daptomycin. In the US, Daptomycin (daptomycin systemic) is a member of the drug class miscellaneous antibiotics and is used to treat Bacteremia, Endocarditis, Methicillin-Resistant Staphylococcus Aureus Infection, Skin and Structure Infection and Skin or Soft Tissue Infection.
What is daptomycin used for?
Daptomycin is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections caused by Gram-positive organisms. It is a naturally occurring compound found in the soil saprotroph Streptomyces roseosporus. Daptomycin has a distinct mechanism of action, disrupting multiple aspects of bacterial cell membrane function.
Is daptomycin expensive?
Cubicin (daptomycin) can cause muscle aches and weakness, which can lead to kidney problems. You might need to have more blood tests done while taking Cubicin (daptomycin). Like most antibiotics, it is common to have diarrhea when taking this medicine. While Cubicin (daptomycin) is generic, it is usually very expensive.