How many people are diagnosed with myelofibrosis?

How many people are diagnosed with myelofibrosis?

Myelofibrosis is a rare condition, with about 1.5 cases reported per 100,000 people each year in the United States. It occurs in both men and women. People of any age can have myelofibrosis, although it is more likely to be diagnosed in people over age 50.

What is the prevalence of myelofibrosis?

Primary myelofibrosis is an uncommon disease, with an annual incidence of approximately 0.5-1.5 cases per 100,000 individuals in the United States. In a review of European data sources, the incidence rate of myelofibrosis ranged from 0.1 to 1 cases per 100,000 per year.

What is the most common MPN?

PV is the most common MPN, accounting for approximately 45% of all MPN cases (Rollison et al., 2008). It is characterized by an increased red blood cell (RBC) volume, as indicated by elevated hemoglobin, hematocrit and red cell mass (Tonkin et al., 2012).

What is the life expectancy of someone with myelofibrosis?

Life expectancy in PMF Primary myelofibrosis, also known as idiopathic myelofibrosis or myelofibrosis with myeloid metaplasia, is a rare disease19, 20 usually affecting elderly people. Median survival ranges from 4 to 5.5 years in modern series6, 7, 8, 9, 10, 11, 12, 13, 14 (Figure 1).

What is blast phase myelofibrosis?

Myelofibrosis (MF) is a clonal stem cell disorder with the potential to transform to acute leukemia, referred to as myelofibrosis in blast phase (MF-BP). The outcome of patients with MF-BP is grave with a median survival of only 2.7 months.

Is myelofibrosis curable?

There is no drug therapy that can cure MF. The only potential cure for MF is allogeneic stem cell transplantation. But this procedure is risky for older patients and those with other health problems. Because MF primarily affects older adults, a stem cell transplantation is not a treatment option for most MF patients.

What is the median survival from time of diagnosis for patients diagnosed with myelofibrosis?

MF, similar to other malignancies, is a serious disease. Published estimates of median survival in primary MF range from 2.25 to 11.25 years, depending on risk level.

Is myelofibrosis an MPN?

Myelofibrosis. Since 2010, myelofibrosis (MF) has been considered a form of cancer. It is one of the three most common myeloproliferative neoplasms (MPN) – rare blood diseases that develop when the bone marrow makes too many blood cells.