Which polymorph of Theobroma oil is most stable?
Upon rescanning, the PKO blend does not show changes in the enthalpy of fusion and the melting point with time, whilst the theobroma oil shows significant reduction, and only regained its thermal stable state after 10 days. This indicates that PKO blend possesses better thermal stability.
Which is the stable form of Theobroma oil?
Theobroma oil, heated to about 60°C and cooled rapidly, will crystallize in an alpha configuration characterized by a melting point below 30°C. The alpha form is metastable and will slowly revert to the beta form, with the characteristic melting point approaching 35°C.
What type of base is Theobroma oil?
FATTY BASES Example: Theobroma oil (Cocoa butter), Synthetic fats. It is a yellowish-white solid having chocolate flavor.
How suppositories are prepared using theobroma oil?
Suppositories are made with clean and non-rancid cocoa butter. The cocoa butter is melted at low heat on the stove. Then herbs or vitamin E or other substances of your choice are added to the melted cocoa butter. If herbs are added, they must be as finely powdered as possible.
What is polymorphism in physical pharmacy?
Polymorphism is the ability of solid materials to exist in two or more crystalline forms with different arrangements or conformations of the constituents in the crystal lattice. More than 50% of active pharmaceutical ingredients (APIs) are estimated to have more than one polymorphic form [1,2].
What is polymorphism and its applications?
Polymorphism is a form of isomerism. Any crystalline material can exhibit the phenomenon. Allotropy refers to polymorphism for chemical elements. Polymorphism is of practical relevance to pharmaceuticals, agrochemicals, pigments, dyestuffs, foods, and explosives.
Is cocoa butter a tropical oil?
We can distinguish 3 groups of tropical fats: those having medium chain fatty acids, like coconut or palm kernel oils, those rich in palmitic acid, like palm oil and its fractions, and those rich in stearic acid like cocoa butter.
Which suppository base causes polymorphism?
This point could be demon- strated by extemporaneous preparations of suppositories containing theobroma oil as their base. Theobroma oil, like many triglycerides, exhibits polymorphism (26). It exists in three different cryslal forms each with different melting points.
What are examples of oily bases?
Fatty bases, also known as oleaginous bases, include synthetic triglyceride mixtures and theobroma oil. Cocoa butter or theobroma oil is used as a suppository base mainly because, in large measure, it accomplishes the requirements of an ideal base.
What is theobroma oil used for?
Cocoa butter, also called theobroma oil, is a pale-yellow, edible fat extracted from the cocoa bean. It is used to make chocolate, as well as some ointments, toiletries, and pharmaceuticals.
Why theobroma oil is not used in suppositories?
Vaginal suppositories are usually oval-shaped and weigh between 3 – 5 grams. Oleaginous bases include theobroma oil (also called cocoa butter) and synthetic triglyceride mixtures. Thus, the finished suppositories would melt at room temperature and not be usable.
What are examples of polymorphs?
Some common examples of polymorphs are calcite and aragonite. The composition of these two minerals is CaCO3, but calcite is rhombohedral while aragonite is orthorhombic. Diamond and graphite , both of which are pure carbon , are also polymorphs.