What is a gemistocytic astrocytoma?
Gemistocytic astrocytomas (GAs) are a distinct variant of astrocytomas, generally classified as WHO grade II, and are associated with an aggressive biological behavior.
What is the prognosis of eggemistocytic astrocytoma?
Gemistocytic astrocytoma is a histologic subtype of low grade astrocytoma, with a poorer prognosis than other matched WHO grade tumors, and with no specific imaging features. For a general discussion of clinical presentation, epidemiology, treatment please refer to the article on low grade astrocytomas.
What is the prognosis of IDH mutant gemistocytic astrocytoma?
Gemistocytic astrocytoma has been associated with early progression and less favorable outcome However, it remains to be determined whether the prognosis of IDH mutant gemistocytic astrocytoma differs significantly from that of IDH mutant diffuse astrocytoma
What is the difference between small and large gemistocytes in colon cancer?
Gemistocytes lack proliferative activity possibly indicating terminal differentiation, while small cells are the proliferating cells and their overall percentage may reflect the biological aggressiveness of these tumors and help to identify GAs of higher grade undergoing malignant progression.
Are microglia immunoreactive in gemistocytic astrocytomas?
A high number of microglia was detected in gemistocytic astrocytomas. More microglia were present if the fraction of gemistocytic tumor cells was high (correlation coefficient = 0.699; P < 0.0002). Interestingly, a number of gemistocytes were immunoreactive for MHC Class II molecules, an observation confirmed by in situ hybridization.
What are the treatment options for astrocytoma?
Astrocytoma treatments include: Surgery to remove the astrocytoma. Radiation therapy. Chemotherapy. Clinical trials. Supportive (palliative) care.