What are Theory of mucoadhesion explain?
Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion, fracture and mechanical. Several in vitro and in vivo methodologies are proposed for studying its mechanisms. However, mucoadhesion is not yet well understood.
Why is mucoadhesion important?
Mucoadhesion is an attractive strategy for buccal drug delivery that involves the interaction between the pharmaceutical dosage form and either secreted mucus or a mucosal membrane [12, 27, 28]. Mucoadhesive properties allow a better contact of the formulation with the buccal mucosa and longer residence times.
What are the stages of mucoadhesion?
The mechanism by which mucoadhesion takes place has been said to have two stages, the contact (wetting) stage followed by the consolidation stage (the establishment of the adhesive interactions). The relative importance of each stage will depend on the individual application.
What is the characteristic of mucoadhesive systems?
11. What is the characteristics of mucoadhesive systems? Explanation: Bio adhesive polymers when they are used as a cross linked polyacrilic acid and are incorporated in a tablet, it allows it to adhere to the gastric mucosa or epithelium.
What is Bioadhesion and Mucoadhesion?
Bioadhesion (and mucoadhesion) is the process whereby synthetic and natural macromolecules adhere to mucosal surfaces in the body. If these materials are then incorporated into pharmaceutical formulations, drug absorption by mucosal cells may be enhanced or the drug released at the site for an extended period of time.
What are bioadhesive materials?
From Wikipedia, the free encyclopedia. Bioadhesives are natural polymeric materials that act as adhesives. The term is sometimes used more loosely to describe a glue formed synthetically from biological monomers such as sugars, or to mean a synthetic material designed to adhere to biological tissue.
What is bioadhesion and mucoadhesion?
What physiological factors affect mucoadhesion?
Several polymer related factors like molecular weight, chain length, degree of cross-linking, hydration, functional groups, charge, polymer concentration and several environmental and physiological factors like contact time, mucin turnover rate and mucus viscosity affect the degree of mucoadhesion.
What is mucoadhesion Slideshare?
•Mucoadhesive drug delivery system interact with the mucus layer covering the mucosal epithelial surface, & mucin molecules & increase the residence time of the dosage form at the site of the absorption. •Mucoadhesive drug delivery system is a part of controlled delivery system.
What is bioadhesion and Mucoadhesion?
What are mucoadhesive DDS applications?
Over the years, mucoadhesive and bioadhesive systems have been used for nasal, ocular, buccal, vaginal, rectal and oral drug delivery.
How does mumucoadhesion work?
Mucoadhesion prolongs the residence time and the contact between membranes and formulations, which allows a sustained drug delivery and reduces the frequency of administration. Many studies describe that the administration of drugs in combination with chitosan increases contact time of chitosan with mucose (Soane et al. 1999 ).
What is mucoadhesiveness and why is it important?
Mucoadhesive drug delivery systems rely on this adhesion to either enhance the delivery of an active ingredient, both systemically or topically, or to enhance coating for some other physical process, such as lubrication. Mucoadhesiveness is therefore a critical quality attribute for many pharmaceuticals or medical devices with relevance to:
What is mucoadhesion in pharmacology?
Mucoadhesion is an attractive strategy for buccal drug delivery that involves the interaction between the pharmaceutical dosage form and either secreted mucus or a mucosal membrane [12, 27, 28]. Mucoadhesive properties allow a better contact of the formulation with the buccal mucosa and longer residence times.
What is mucoadhesive drug delivery?
Mucoadhesion describes the adhesion of a product to a mucous membrane. Mucoadhesive drug delivery systems rely on this adhesion to either enhance the delivery of an active ingredient, both systemically or topically, or to enhance coating for some other physical process, such as lubrication.