Can amlodipine cause gum hyperplasia?
Gingival enlargement is one of the side effects associated with certain drugs. Amlodipine, a calcium channel blocker, used as antihypertensive drug has been found associated with gingival hyperplasia.
Why do calcium channel blockers cause gingival hyperplasia?
The present study proposes a mechanism by which calcium channel antagonists may induce gingival hyperplasia. The calcium antagonist induces blockage of the aldosterone synthesis in zona glomerulosa of the adrenal cortex since this pathway is calcium-dependent, cyclic nucleotide-independent.
What blood pressure medications cause gingival hyperplasia?
Phenytoin, phenobarbital, valproate, cyclosporine, tacrolimus, nifedipine, verapamil, and amlodipine are known to cause gingival overgrowth3,5,6,8-11; these drugs affect fibroblast function, increasing the matrix of the gingival connective tissue.
Can amlodipine cause gums to bleed?
In some patients, tenderness, swelling, or bleeding of the gums may appear soon after treatment with this medicine is started. Brushing and flossing your teeth carefully and regularly and massaging your gums may help prevent this.
How common is gingival hyperplasia with amlodipine?
Amlodipine is a second-generation dihydropyridine calcium channel blocker that can cause gingival hypertrophy. The prevalence of amlodipine-induced gingival hypertrophy has been shown to be between 1.7% and 3.3%.
Does amlodipine cause lip swelling?
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, when you first start taking amlodipine, your angina may get worse or you could have a heart attack.
Do calcium channel blockers cause gingivitis?
This benign oral condition is a common side effect of the majority of CCBs. It is characterized by an increase of the gingival mass and volume, which can range from mild to extremely severe. Among calcium antagonists, nifedipine is the most frequently implicated antagonist in drug-induced gingival overgrowth.
What is an alternative to amlodipine?
There are several other calcium channel blockers that work in the same way as amlodipine. They include nifedipine, felodipine, lacidipine and lercanidipine. There are other calcium channel blockers, such as diltiazem and verapamil, that have other effects on the heart.
What are the side effects of amlodipine?
Amlodipine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- swelling of the hands, feet, ankles, or lower legs.
- headache.
- upset stomach.
- nausea.
- stomach pain.
- dizziness or lightheadedness.
- drowsiness.
- excessive tiredness.
Why is amlodipine being recalled?
Citing defective bottles that may not seal appropriately and protect from moisture, Pfizer Inc. is recalling two lots of Caduet (amlodipine besylate/atorvastatin calcium) tablets. The recall was announced in the February 19, 2020, US Food and Drug Administration (FDA) Enforcement Report.
How does amlodipine affect the gums?
How long does it take for gingival hyperplasia to go away?
How long does it take for gingival hyperplasia to go away? After you stop taking the medication(s) that caused gingival hyperplasia or start treatment for the condition, it takes one to eight weeks for the lesions to disappear.
What drugs cause gingival hyperplasia?
Calcium channel blockers; specifically Nifedipine and Verapamil
What are the causes of gingival hyperplasia?
Inflammatory gum enlargement Gingival hyperplasia can occur as a direct result of inflammation.
Does nifedipine cause gingival hyperplasia?
, Nifedipine Induces Gingival Epithelial Hyperplasia in Rats Through Inhibition of Apoptosis, Journal of Periodontology, 73, 8, (861-867), (2002). , Inhibition by nifedipine of adherence- and activated macrophage-induced death of human gingival fibroblasts, European Journal of Pharmacology, 415, 1, (95), (2001).
How does nifedipine cause gingival hyperplasia?
The nifedipine-induced gingival hyperplasia may be probably caused by alterations in calcium metabolism. The withdrawal of the drug results in a complete remission of the disease.