What causes hyperlipoproteinemia type 1?

What causes hyperlipoproteinemia type 1?

Type I hyperlipoproteinemia can also be due to a deficiency of apo C-II, an essential cofactor for LPL, or to the presence of an inhibitor of LPL in the plasma. Hyperchylomicronemia may be accompanied by an increase in VLDL (type V hyperlipoproteinemia) in which LPL is not absent but may be defective.

What are the symptoms of Type 5 hyperlipoproteinemia?

Type 5 runs in families. It involves high levels of LDL alone or together with VLDL. Lipid deposits are the main symptom of hyperlipoproteinemia. The location of lipid deposits can help to determine the type. Some lipid deposits, called xanthomas, are yellow and crusty. They occur on your skin.

What are the treatment options for hyperlipoproteinemia?

Treatment for hyperlipoproteinemia will depend on which type you have. When the condition is the result of hypothyroidism, diabetes, or pancreatitis, treatment will take the underlying disorder into account. Your doctor may prescribe medications like the following to help lower lipid levels:

What are the phenotypes of dysbetalipoproteinemia?

Patients with dysbetalipoproteinemia exhibit phenotype E-2:E-2; apo E-2, which is different from the predominant wild-type apo E-3, is known as mutant E-2. Apo E-2 has a much lower affinity (1%) for the hepatic receptors compared with other phenotypes. Type III hyperlipoproteinemia is a multifactorial disorder.