How does pravastatin lower cholesterol?
Pravastatin may be used for the treatment of high cholesterol or to lower triglycerides. Pravastatin works by blocking an enzyme, called HMG-CoA reductase, in the liver that makes different types of lipids (this is the collective term for fats and cholesterol). Pravastatin also boosts the breakdown of lipids.
What is the mechanism of action of atorvastatin?
Mechanism of Action Atorvastatin competitively inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. [2] By preventing the conversion of HMG-CoA to mevalonate, statin medications decrease cholesterol production in the liver.
Does pravastatin lower LDL?
Pravastatin significantly lowered plasma total and LDL cholesterol levels by 21% and 32%, respectively. Triglyceride levels did not change, and apolipoprotein B (apoB) concentrations decreased by 9% (P = NS).
Is pravastatin a vasodilator?
Background: Pravastatin has been found to have clinical benefits beyond those predicted by its actions in reducing plasma low density lipoprotein cholesterol (LDL). Both PRA and simvastatin (SIM) are equally effective in reducing LDL, but only PRA reduces platelet aggregation and is an effective vasodilator.
What are the functional groups of pravastatin?
Pravastatin is a carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid.
Can Pravastatin raise blood pressure?
Pravastatin decreases blood pressure in hypertensive and hypercholesterolemic patients receiving antihypertensive treatment.
Does Pravastatin remove plaque from arteries?
Conclusions. The results of this study indicate that pravastatin has effects on the artery wall independent of its effects on plasma lipoprotein concentrations. These include favorable effects on coronary artery vascular reactivity and a shift away from plaque characteristics associated with plaque rupture.
What is carvedilol mechanism of action?
Carvedilol works by blocking the action of certain natural substances in your body, such as epinephrine, on the heart and blood vessels. This effect lowers your heart rate, blood pressure, and strain on your heart. Carvedilol belongs to a class of drugs known as alpha and beta-blockers.
Is atorvastatin an inhibitor?
LIPITOR® (atorvastatin calcium) is a synthetic lipid-lowering agent. Atorvastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis.
Does Pravastatin affect HDL?
In patients treated with pravastatin, there was no apparent additional effect due to HDL-cholesterol in terms of reduction of events, and cardiovascular risk remained very high in patients with low levels of HDL-cholesterol (Fig. 5).
Do statins constrict blood vessels?
Statins also help to relax the blood vessels, which leads to a decrease in blood pressure.
What is the mechanism of action of promethazine?
Promethazine hydrochloride selectively blocks peripheral H1 receptors thereby diminishing the effects of histamine on effector cells. Promethazine hydrochloride also blocks the central histaminergic receptors, thereby depressing the reticular system causing sedative and hypnotic effects.
What is the mechanism of action of a statin?
Statins: Mechanism of Action. Statins act by competitively inhibiting HMG-CoA reductase, the first and key rate-limiting enzyme of the cholesterol biosynthetic pathway. Statins mimic the natural substrate molecule, HMG-CoA, and compete for binding to the HMGCR enzyme. This competition slows the rate of mevalonate production,…
What is the mechanism of action of narcotics?
The mechanism of action for these narcotics are that they stimulate endorphin receptors. By stimulating this receptor, it blocks the perception of pain. Remember again, that pain is a symptom. A message is being sent by the body to the brain that there is this pain.
What is the mechanism of action of chemotherapy?
Cytotoxic chemotherapy refers to agents whose mechanisms of action cause cell death or prevent cell growth, generally through inhibiting microtubule function, protein function, or DNA synthesis. Cytotoxic chemotherapy mechanisms of action may be cell cycle-dependent—arresting cancer cell growth at specific phases in the cell cycle.